Involvement of CO2 generated by urease in multiplication of Helicobacter pylori

Helicobacter pylori (H. pylori) urease generates both ammonia (NH3) and carbon dioxide (CO2) from urea. NH3 helps H. to survive in the stomach part by neutralizing gastric acid. However, relationship between CO2 is not completed cleared. We examined effect of generated on multiplication using isogenic ureB mutant complemented strain JP26. Wild-type survived medium supplement with 1mM urea room air, however, negative did not. To discern whether was incorporated into pylori, 14C bacillus counted after 6 hours incubation acidic neutral medium. Significant more uptake detected wild-type compared this under condition condition, but no difference identified strain. These results suggest that plays a role pylori.